A Structure-function Analysis of the Nef Protein of Primate Lentiviruses
نویسنده
چکیده
Nef is one of the five so-called auxiliary genes of primate lentiviruses, a group that also includes vif, vpr, vpu (in HIV-1 and SIVCPZ), and vpx (in HIV-2 and other SIV strains). Inactivating these genes does not completely prevent viral replication in cell culture (reviewed in (Cullen, 1998)), but studies conducted both in SIV-infected monkeys and in HIV-infected individuals have revealed that they encode important virulence factors. Three major functions of Nef have been uncovered through in vitro analyses: the downregulation of CD4 and MHC class I, the stimulation of virion infectivity, and the capacity to alter the activation state of cells.
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تاریخ انتشار 2000